Inflammation and Transplantation

The central problem in transplantation is the immune response of the host against graft antigens (Ags) of the donor. T cells play a more dominant role in the rejection response than B cells. T-helpers (Ths) types are classified as Th1 and Th2 cytokines. They are the key mediators in the induction/effecter phases of all immune and inflammatory responses. Cytokines are playing a vital role in acute/chronic allograft rejection. Several studies lead to the identification of patient risk profiles enabling individualization of level of immunosuppression.

Cytokine testing helps in pre-assessment of allograft outcome and to optimize cyclosporine therapy in post-transplant patients. Studies have shown that the use of immunosuppressive drugs requires a fine balance between adequate immunosuppressant to prevent rejection and excessive dosage leading to toxicity.

Pre-transplantation assessment and testing for the cytokine levels is a powerful tool for better choice of immunosuppressive agents for optimization of patient immunosuppressive therapy. Genetic variations in genes encoding different Th1 and Th2 cytokines, chemokines and their receptors impact the success of engraftment as it interacts with proteins used as substrates of immunosuppressive drugs.

The cytokine panel as a group of inflammatory mediators, 12 cytokines and chemokines are measured from one blood sample. There is a strong body of literature as scientific evidences to suggest that the inflammation process and its early link for early prediction of  organ rejection.The good thing is that we have a group of proteins that are working and lined together that can be measured through a simple methodology to reveal the whole picture. 

Ask your doctor about the Biomarker testing. The biomarker's testing as preventive medicine: a new approach to stay healthy. Biomarkers are useful for:

• Disease prevention and screening
• Monitoring disease progress and response to treatment
• Drug selection

Our laboratory services are for informational purposes only. It is not the intention of Canada Metabolic Inflammation Diagnostics Inc. to provide specific medical advice but rather to provide users with information to better understand their health. Specific medical advice including diagnosis and treatment will not be provided. Always seek the advice of a trained health professional for medical adivce, diagnosis or treatment.