Physical inactivity results in lower energy expenditure, and as a result is a major contributor to cardiovascular diseases, such as coronary artery disease and stroke, which are considered major causes of disability and mortality worldwide. Exercise contributes to reduced levels of inflammatory markers in individuals with enhanced chronic inflammation. This has been seen in inflammation related proteins such as tutor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) and nuclear factor kappa B.
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